Genetics and epigenetics in small intestinal neuroendocrine tumours
نویسندگان
چکیده
منابع مشابه
Small Intestinal Neuroendocrine Tumours
Edfeldt, K. 2014. Small Intestinal Neuroendocrine Tumours. Genetic and Epigenetic Studies and Novel Serum Biomarkers. Digital Comprehensive Summaries of Uppsala Dissertations from the Faculty of Medicine 975. 51 pp. Uppsala: Acta Universitatis Upsaliensis. ISBN 978-91-554-8887-1. Small intestinal neuroendocrine tumours (SI-NETs) are rare, hormone producing and proliferate slowly. Patients usual...
متن کاملMelatonin Immunoreactivity in Malignant Small Intestinal Neuroendocrine Tumours
BACKGROUND/AIMS Small intestinal neuroendocrine tumours (SI-NETs) are derived from enterochromaffin cells. After demonstrating melatonin in enterochromaffin cells, we hypothesized that SI-NETs may express and secrete melatonin, which may have an impact on clinical factors and treatment response. METHODS Tumour tissue from 26 patients with SI-NETs, representing paired sections of primary tumou...
متن کاملGenetics of neuroendocrine and carcinoid tumours.
Neuroendocrine tumours (NETs) originate in tissues that contain cells derived from the embryonic neural crest, neuroectoderm and endoderm. Thus, NETs occur at many sites in the body, although the majority occur within the gastro-entero-pancreatic axis and can be subdivided into those of foregut, midgut and hindgut origin. Amongst these, only those of midgut origin are generally argentaffin posi...
متن کاملSmall Intestinal Tumours
Objective. Balloon enteroscopy (BE) and capsule enteroscopy (CE) are enteroscopy methods that allow examination and treatment of the small bowel. Before the CE and BE era, the small intestine was difficult to access for investigation. Small intestinal tumours are infrequent conditions, but about half of them are malignant. Materials and Methods. A total of 303 BEs were performed in 179 patients...
متن کاملPD-L1 expression and presence of TILs in small intestinal neuroendocrine tumours
Background The extent of resistance to immune surveillance in patients with well-differentiated (Wd) (grade 1/2) small-intestinal neuroendocrine tumours (Si-NETs) is unknown. Methods Patients diagnosed with Wd Si-NETs (excluding appendix, which are considered to have a different biology to other midgut NETs) were eligible. Tumoural programmed death (PD)-ligand(L) 1 (PD-L1)/PD-L2/PD-1 and tumo...
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ژورنال
عنوان ژورنال: Journal of Internal Medicine
سال: 2016
ISSN: 0954-6820
DOI: 10.1111/joim.12526